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Article

Proton-gating of opioid receptors and isoform functionality

2026-05-29

Abstract excerpt

The three opioid receptors, mu (mu-OR), delta (delta-OR), and kappa (kappa-OR), are key G-protein-coupled receptors (GPCRs) involved in mediating pain relief. Yet, there has been a lack of understanding regarding how changes in the extracellular pH associated with inflammation affect their signal transduction pathways. This study demonstrates that all opioid receptors act as proton-gated coincidence detectors. A h...

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Identifiers and source

Literature Corpus work
79e27db2-f6f9-5c15-ab14-01efc9410236
DOI
10.64898/2026.05.26.727816
Open publication

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Proton-gating of opioid receptors and isoform functionalityDOI 10.64898/2026.05.26.727816
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