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Article

Precision genome editing using cytosine and adenine base editors in mammalian cells.

Nature protocols - 1 Feb 2021

Huang Tony P, Newby Gregory A, Liu David R

Abstract excerpt

Genome editing has transformed the life sciences and has exciting prospects for use in treating genetic diseases. Our laboratory developed base editing to enable precise and efficient genome editing while minimizing undesired byproducts and toxicity associated with double-stranded DNA breaks. Adenine and cytosine base editors mediate targeted A•T-to-G•C or C•G-to-T•A base pair changes, respectively, which can...

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Identifiers

PMID: 33462442
DOI: 10.1038/s41596-020-00450-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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