Article

Dynamic tissue-specific H2Bub1 is required for human and mouse cardiogenesis

2022-04-01

Abstract excerpt

<title>Abstract</title> <p>De novo variants affecting the core complex required for monoubiquitination of histone H2B (H2Bub1) are enriched in human congenital heart disease. H2Bub1 is an enigmatic chromatin modification required in stem cell differentiation, cilia function, post-natal cardiomyocyte maturation and transcriptional elongation. However, it is still unknown how H2Bub1 affects cardiogenesis (heart str...

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Literature Corpus work: 8e70a550-bc7b-5b7b-b303-38bfafe607a5
DOI: 10.21203/rs.3.rs-1498907/v1

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