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Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility

24 Jun 2019

Abstract excerpt

Genomic analyses of patients with congenital heart disease (CHD) have identified significant contribution from mutations affecting cilia genes and chromatin remodeling genes; however, the mechanism(s) connecting chromatin remodeling to CHD is unknown. Histone H2B monoubiquitination (H2Bub1) is catalyzed by the RNF20 complex consisting of RNF20, RNF40, and UBE2B. Here, we show significant enrichment of...

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PMID: 31235600
DOI: 10.1073/pnas.1808341116

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