Article

Tissue-specific H2Bub1 is required for cardiomyocyte development

2021-08-24

Abstract excerpt

<title>Abstract</title> <p>De-novo mutations affecting Histone2B-K120 monoubiquitination (H2Bub1) are enriched in congenital heart disease; however, how H2Bub1 affects heart development beyond its function in establishing left-right asymmetry remains unknown. Here we show that the RNF20-core complex (RNF20-RNF40-UBE2B), which catalyzes H2Bub1, is required for cardiac development in-vivo in mice and in-vitro in iP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6286da6a-9aac-56e8-9eb1-0f2d6966323a
DOI: 10.21203/rs.3.rs-788134/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific H2Bub1 is required for cardiomyocyte developmentDOI 10.21203/rs.3.rs-788134/v1Read

Dynamic tissue-specific H2Bub1 is required for human and mouse cardiogenesisSemantic proximity Read

Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motilitySemantic proximity Read

In vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturationSemantic proximity Read

Gene body H2B monoubiquitylation regulates gene-selective RNA Polymerase II pause release and is not rate limiting for transcription elongationSemantic proximity Read

Chromatin state transition underlies the temporal changes in gene expression during cardiomyocyte maturationSemantic proximity Read

TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart FailureSemantic proximity Read

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read

Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.Semantic proximity Read

Loss of H2B monoubiquitination is associated with poor‐differentiation and enhanced malignancy of lung adenocarcinomaSemantic proximity Read

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte functionSemantic proximity Read

The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases.Semantic proximity Read

Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20Semantic proximity Read