Article
Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.
Circulation research - 3 Aug 2018
Boogerd Cornelis J, Zhu Xiaoming, Aneas Ivy, Sakabe Noboru, Zhang Lunfeng, Sobreira Debora R, Montefiori Lindsey, Bogomolovas Julius, Joslin Amelia C, Zhou Bin, Chen Ju, Nobrega Marcelo A, Evans Sylvia M
Abstract excerpt
RATIONALE: Mutations in the transcription factor TBX20 (T-box 20) are associated with congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development and embryonic lethality by embryonic day 9.5. Because Tbx20 is expressed in multiple cell lineages required for myocardi...
Topics
- Animals
- Cell Line
- Cell Proliferation
- Cells, Cultured
- G1 Phase
- Gene Expression Regulation, Developmental
- Heart Atria
- Mice
- Mice, Inbred C57BL
- Mutation
- Myocytes, Cardiac
- S Phase
- T-Box Domain Proteins