Article
The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases.
Genes - 8 Apr 2020
Fochi Stefania, Lorenzi Pamela, Galasso Marilisa, Stefani Chiara, Trabetti Elisabetta, Zipeto Donato, Romanelli Maria Grazia
Abstract excerpt
Alternative splicing is a regulatory mechanism essential for cell differentiation and tissue organization. More than 90% of human genes are regulated by alternative splicing events, which participate in cell fate determination. The general mechanisms of splicing events are well known, whereas only recently have deep-sequencing, high throughput analyses and animal models provided novel information on the network...
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