Article

Polygenic risk score analysis suggests hypothyroidism as a risk factor for Alzheimer’s disease

2024-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Utilizing the All of Us cohort, this study explores the relationship between clinical conditions, and AD risk, shedding light on potential preventative measures. We selected a subset of non-AD affected individuals aged 60 and older (n = 72,044). Polygenic Risk Scores (PRS) were calculated to assess AD risk, which were then associated with medical conditions. A replication study was conducted in t...

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Literature Corpus work: a73dd05c-e337-5d78-afbf-3c1233b7b975
DOI: 10.1101/2024.10.13.24315421

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