Article

Deletion or inhibition of PTPRO mitigates diet-induced hepatic steatosis and inflammation in obesity

2022-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Chronic inflammation plays crucial roles in obesity-induced metabolic diseases. We herein demonstrated that mice lacking the protein tyrosine phosphatase receptor type O (PTPRO) exhibited the hyper-obese phenotype when fed a high-fat/high-sucrose diet. However, Ptpro -KO mice with hyperobesity showed the markedly small accumulation of ectopic fat in the liver, improvements in lipid and glucose...

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Literature Corpus work: 8dff7225-a42a-53ba-bd2a-91367f681c5f
DOI: 10.1101/2022.09.05.506586

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