Article
Protein kinase Cβ deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling.
Journal of lipid research - 1 Mar 2012
Huang Wei, Bansode Rishipal R, Bal Naresh C, Mehta Madhu, Mehta Kamal D
Abstract excerpt
To explore the role of leptin in PKCβ action and to determine the protective potential of PKCβ deficiency on profound obesity, double knockout (DBKO) mice lacking PKCβ and ob genes were created, and key parameters of metabolism and body composition were studied. DBKO mice had similar caloric intake as ob/ob mice but showed significantly reduced body fat content, improved glucose metabolism, and elevated body...
Topics
- Adipose Tissue, Brown
- Adipose Tissue, White
- Animals
- Blotting, Western
- Diet, High-Fat
- Eating
- Genotype
- In Vitro Techniques
- Male
- Mice
- Mice, Knockout
- Mice, Obese
- Obesity
- Oxygen Consumption
- Protein Kinase C