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Article

FTO is a relevant factor for the development of the metabolic syndrome in mice.

PloS one - 1 Jan 2014

Ikels Kathrin, Kuschel Stefanie, Fischer Julia, Kaisers Wolfgang, Eberhard Daniel, Rüther Ulrich

Abstract excerpt

The metabolic syndrome is a worldwide problem mainly caused by obesity. FTO was found to be a obesity-risk gene in humans and FTO deficiency in mice led to reduction in adipose tissue. Thus, FTO is an important factor for the development of obesity. Leptin-deficient mice are a well characterized model for analysing the metabolic syndrome. To determine the relevance of FTO for the development of the metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25144618
DOI: 10.1371/journal.pone.0105349
PMCID: PMC4140775

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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