Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation.

doi:10.1002/hep.27233

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Article

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation.

Hepatology (Baltimore, Md.) - 1 Oct 2014

Chatzigeorgiou Antonios, Chung Kyoung-Jin, Garcia-Martin Ruben, Alexaki Vasileia-Ismini, Klotzsche-von Ameln Anne, Phieler Julia, Sprott David, Kanczkowski Waldemar, Tzanavari Theodora, Bdeir Mohktar, Bergmann Sibylle, Cartellieri Marc, Bachmann Michael, Nikolakopoulou Polyxeni, Androutsellis-Theotokis Andreas, Siegert Gabriele, Bornstein Stefan R, Muders Michael H, Boon Louis, Karalis Katia P, Lutgens Esther, Chavakis Triantafyllos

Abstract excerpt

UNLABELLED: The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells and hepatic parenchymal cells contribute to the exacerbation of liver inflammation and steatosis in obesity. The costimulatory molecules, B7.1 and B7.2,...

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PMID: 24845056
DOI: 10.1002/hep.27233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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