Article
PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.
Scientific reports - 14 Sept 2017
Shintani Takafumi, Higashi Satoru, Suzuki Ryoko, Takeuchi Yasushi, Ikaga Reina, Yamazaki Tomomi, Kobayashi Kenta, Noda Masaharu
Abstract excerpt
Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity. We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in hypothalamic neurons together with leptin receptors, and that PTPRJ negatively regulates leptin signaling by...
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