Article
Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice.
American journal of physiology. Endocrinology and metabolism - 1 Jan 2007
Gao Zhanguo, Wang Zhong, Zhang Xiaoying, Butler Andrew A, Zuberi Aamir, Gawronska-Kozak Barbara, Lefevre Michael, York David, Ravussin Eric, Berthoud Hans-Rudolf, McGuinness Owen, Cefalu William T, Ye Jianping
Abstract excerpt
In this study, we investigated the metabolic phenotype of PKCtheta knockout mice (C57BL/6J) on chow diet and high-fat diet (HFD). The knockout (KO) mice are normal in growth and reproduction. On the chow diet, body weight and food intake were not changed in the KO mice; however, body fat content was increased with a corresponding decrease in body lean mass. Energy expenditure and spontaneous physical activity...
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