Article

Exploring the Role of YAP1 and TAZ in Pancreatic Acinar Cells and the Therapeutic Potential of VT-104 in Pancreatic Inflammation

2023-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Increasing evidences have linked the hippo pathway with the fibroinflammatory diseases. We generated a series of genetic knockout mice for targeting the key components of Hippo pathway to examine the individual effects of YAP1 and TAZ on pancreatic inflammation and evaluated the therapeutic potential of the YAP1/TAZ inhibitor VT-104. Mice with acinar-specific knockout of YAP1/TAZ did not exhibit...

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Literature Corpus work: 85b850ce-d2d9-5b00-a167-925b9b2761ca
DOI: 10.1101/2023.09.18.558321

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