Article
Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice.
Biochimica et biophysica acta - 1 Feb 2015
Gao Xia, van der Veen Jelske N, Hermansson Martin, Ordoñez Marta, Gomez-Muñoz Antonio, Vance Dennis E, Jacobs René L
Abstract excerpt
Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT, Pemt(-/-) mice) are resistant to high-fat diet (HFD)-induced obesity (DIO) but develop non-alcoholic steatohepatitis. PEMT expression is strongly induced during differentiation of 3T3-L1 adipocytes. Hence, we hypothesized that white adipose tissue (WAT) might be a key player in the protection against DIO in Pemt(-/-) mice. We fed Pemt(-/-) and...
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