Article
Deletion of nuclear factor-κB p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice.
American journal of physiology. Endocrinology and metabolism - 15 Sept 2015
Minegishi Yoshihiko, Haramizu Satoshi, Misawa Koichi, Shimotoyodome Akira, Hase Tadashi, Murase Takatoshi
Abstract excerpt
The transcription factor nuclear factor-κB (NF-κB) plays an important role in regulating physiological processes such as immunity and inflammation. In addition to this primary role, NF-κB interacts physically with peroxisome proliferator-activated receptors regulating lipid metabolism-related gene expression and inhibits their transcriptional activity. Therefore, inhibition of NF-κB may promote fatty acid...
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