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Article

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism.

FEBS open bio - 1 Mar 2020

Hoshino Shunsuke, Kobayashi Masaki, Tagawa Ryoma, Konno Ryutaro, Abe Takuro, Furuya Kazuhiro, Miura Kumi, Wakasawa Hiroki, Okita Naoyuki, Sudo Yuka, Mizunoe Yuhei, Nakagawa Yoshimi, Nakamura Takeshi, Kawabe Hiroshi, Higami Yoshikazu

Abstract excerpt

White adipose tissue (WAT) is important for maintenance of homeostasis, because it stores energy and secretes adipokines. The WAT of obese people demonstrates mitochondrial dysfunction, accompanied by oxidative stress, which leads to insulin resistance. WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a member of the HECT-type E3 family of ubiquitin ligases and is associated with several diseases....

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Share to Adipose Tissue, White
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31965758
DOI: 10.1002/2211-5463.12795
PMCID: PMC7050250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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