Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.

doi:10.1038/s41467-021-27601-0

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Article

Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.

Nature communications - 14 Jan 2022

Sanders Bret, D'Andrea Daniel, Collins Mark O, Rees Elliott, Steward Tom G J, Zhu Ying, Chapman Gareth, Legge Sophie E, Pardiñas Antonio F, Harwood Adrian J, Gray William P, O'Donovan Michael C, Owen Michael J, Errington Adam C, Blake Derek J, Whitcomb Daniel J, Pocklington Andrew J, Shin Eunju

Abstract excerpt

Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem cells into cortical excitatory neurons. We identify transcriptional programs expressed during early neurogenesis in...

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PMID: 35031607
DOI: 10.1038/s41467-021-27601-0
PMCID: PMC8760302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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