Article

Transcriptional regulation of schizophrenia risk gene TCF4 in inhibitory neurons during neurodevelopment

2021-03-05

Abstract excerpt

The pathology underlying schizophrenia (SCZ) involves cell type-specific and developmental stage-specific dysregulation of multiple gene regulatory networks dominated by some key transcription factors, such as SCZ risk gene transcription factor 4 (TCF4). Previous studies on the regulatory mechanism of TCF4 use SY5Y as the cellular model, which could not reflect its cell typespecific role in the real world. Using t...

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Literature Corpus work: 2de29ecf-11d9-5099-8555-53e6a3acf012
DOI: 10.1101/2021.03.04.433878

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