Article

Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia

2017-05-02

Abstract excerpt

Tissue-specific reverse engineering of transcriptional networks has uncovered master regulators (MRs) of cellular networks in various cancers, yet the application of this method to neuropsychiatric disorders is largely unexplored. Here, using RNA-Seq data on postmortem dorsolateral prefrontal cortex (DLPFC) from schizophrenia (SCZ) patients and control subjects, we deconvolved the transcriptional network to identi...

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Literature Corpus work: 1d0279cf-f354-5264-921c-35aea08df7ac
DOI: 10.1101/133363

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