Article

A schizophrenia-associated radial glia cell state perturbs early human brain development

2025-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Multidisciplinary evidence support a neurodevelopmental origin for schizophrenia, yet the mechanistic translation of known risk factors remains poorly understood. In this study, we leverage multi-lineage, forebrain-patterned organoids derived from monozygotic twins discordant for schizophrenia, integrating single-cell transcriptomic and epigenomic profiling to uncover disease-associated gene exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08570887-6e3c-5c29-856b-00074a341812
DOI: 10.1101/2025.10.24.684395

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A schizophrenia-associated radial glia cell state perturbs early human brain developmentDOI 10.1101/2025.10.24.684395Read

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genesSemantic proximity Read

Single-cell dissection of schizophrenia reveals neurodevelopmental-synaptic axis and transcriptional resilienceSemantic proximity Read

Dysregulation of miRNAs Drives Premature GABAergic Maturation and Early Neurodevelopmental Defects in SchizophreniaSemantic proximity Read

Mapping the Cellular Etiology of Schizophrenia and Diverse Brain PhenotypesSemantic proximity Read

Longitudinal Transcriptomic Analysis of Human Cortical Spheroids Identifies Axonal Dysregulation in the Prenatal Brain as a Mediator of Genetic Risk for Schizophrenia.Semantic proximity Read

Identification of neuron-glia signaling feedback in human schizophrenia using patient-derived, mix-and-match forebrain assembloidsSemantic proximity Read

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophreniaSemantic proximity Read

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoidsSemantic proximity Read

The Genesis of Schizophrenia: An Origin Story.Semantic proximity Read

Human-specific enrichment of schizophrenia risk-genes in callosal neurons of the developing neocortexSemantic proximity Read

Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoidsSemantic proximity Read

Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brainsSemantic proximity Read