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Article

Deconvolution of cell type-specific drug responses in human tumor tissue with single-cell RNA-seq

11 May 2021

Abstract excerpt

BACKGROUND: Preclinical studies require models that recapitulate the cellular diversity of human tumors and provide insight into the drug sensitivities of specific cellular populations. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity. METHODS: We combine multiplexed drug...

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PMID: 33975634
DOI: 10.1186/s13073-021-00894-y

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