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Article

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma

25 Jun 2019

Abstract excerpt

BACKGROUND: A major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials, patient heterogeneity in response to therapy is commonly observed; however, how tumor heterogeneity is reflected in individual drug sensitivities in the treatment-naïve glioblastoma stem cells (GSC) is unclear. METHODS: We cultured 12...

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PMID: 31238897
DOI: 10.1186/s12885-019-5861-4

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