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Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative Diseases

1 Jan 2014

Abstract excerpt

The ubiquitin proteasome system (UPS) is the primary proteolytic quality control system in cells and has an essential function in the nervous system. UPS dysfunction has been linked to neurodegenerative conditions, including Alzheimer's, Parkinson's and Huntington's diseases. The pathology of neurodegenerative diseases is characterized by the abnormal accumulation of insoluble protein aggregates or inclusion...

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PMID: 25413678
DOI: 10.1159/000367694

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