Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease

29 Mar 2016

Abstract excerpt

The cellular quality control system degrades abnormal or misfolded proteins and consists of three different mechanisms: the ubiquitin proteasomal system (UPS), autophagy and molecular chaperones. Any disturbance in this system causes proteins to accumulate, resulting in neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer's disease (AD), Parkinson's disease, Huntington's disease and prion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27028664
DOI: 10.1111/jcmm.12817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's diseasePMID 27028664Read ↗

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.Semantic proximity Read ↗

Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative DiseasesSemantic proximity Read ↗

The role of the ubiquitin proteasome system in Alzheimer's diseaseSemantic proximity Read ↗

The Ubiquitin-Proteasome System in NeurodegenerationSemantic proximity Read ↗

Mechanism of neurodegenerative disease: role of the ubiquitin proteasome systemSemantic proximity Read ↗

The ubiquitin‐proteasome system in Alzheimer's diseaseSemantic proximity Read ↗

The Ubiquitin Proteasome System in Neurodegenerative DiseasesSemantic proximity Read ↗

Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies.Semantic proximity Read ↗

The ubiquitin-proteasome system and neurodegenerative disorders.Semantic proximity Read ↗

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunitiesSemantic proximity Read ↗

Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesisSemantic proximity Read ↗

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.