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Quantitative analysis of synaptic pathology and neuroinflammation: an initial study in a female rhesus monkey model of the “synaptic” phase of Alzheimer’s disease

2018-01-19

Abstract excerpt

<h4>Background</h4> Soluble oligomers of the Aβ peptide (AβOs) are toxins that target and disrupt synapses. Generation of AβOs has been recently recognized as a probable initiating event in Alzheimer’s disease (AD), leading to cognitive impairment. There is a translational gap in AD studies, with promising drugs developed based on work in rodent models failing in AD patients in clinical trials. Additionally, alth...

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Literature Corpus work
8ddd4314-74e6-5c80-b2e5-6600547d9db0
DOI
10.1101/251025
Open publication

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