Article

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

2023-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). There is increasing evidence that depression may precede AD and may be an early manifestation of dementia, suggesting common mechanisms underlying both diseases. Ligands targeting the mitochondrial translocator protein (18 kDa) (TSPO), promote neurosteroidogenesis and may be neuroprotective. Moreover, TSPO i...

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Literature Corpus work: 178bbf43-8a3d-538c-b375-f5146f96a439
DOI: 10.1101/2023.02.23.529740

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