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Article

Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Willén Katarina, Sroka Agnieszka, Takahashi Reisuke H, Gouras Gunnar K

Abstract excerpt

Alzheimer's disease (AD) is increasingly viewed as a disease of synapses. Loss of synapses correlates better with cognitive decline than amyloid plaques and neurofibrillary tangles, the hallmark neuropathological lesions of AD. Soluble forms of amyloid-β (Aβ) have emerged as mediators of synapse dysfunction. Aβ binds to, accumulates, and aggregates in synapses. However, the anatomical and neurotransmitter...

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Identifiers

PMID: 28869466
DOI: 10.3233/JAD-170262
PMCID: PMC5611798

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