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Article

Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2024

Beckman Danielle, Diniz Giovanne B, Ott Sean, Hobson Brad, Chaudhari Abhijit J, Muller Scott, Chu Yaping, Takano Akihiro, Schwarz Adam J, Yeh Chien-Lin, McQuade Paul, Chakrabarty Paramita, Kanaan Nicholas M, Quinton Maria S, Simen Arthur A, Kordower Jeffrey H, Morrison John H

Abstract excerpt

INTRODUCTION: The understanding of the pathological events in Alzheimer's disease (AD) has advanced dramatically, but the successful translation from rodent models into efficient human therapies is still problematic. METHODS: To examine how tau pathology can develop in the primate brain, we injected 12 macaques with a dual tau mutation (P301L/S320F) into the entorhinal cortex (ERC). An investigation was performed...

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Identifiers

PMID: 39030748
DOI: 10.1002/alz.13868
PMCID: PMC11350056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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