Article

Incorporating family history of disease improves polygenic risk scores in diverse populations

2021-04-15

Abstract excerpt

Polygenic risk scores derived from genotype data (PRS) and family history of disease (FH) both provide valuable information for predicting disease risk, enhancing prospects for clinical utility. PRS perform poorly when applied to diverse populations, but FH does not suffer this limitation. Here, we explore methods for combining both types of information (PRS-FH). We analyzed 10 complex diseases from the UK Biobank...

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Literature Corpus work: 8dd6b3a6-765d-52ba-b85d-e08dad1cbed3
DOI: 10.1101/2021.04.15.439975

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