Article

Development and validation of polygenic scores for within-family prediction of disease risks

2025-08-08

Abstract excerpt

The clinical implementation of polygenic scores (PGSs) for disease risk prediction, particularly in reproductive health applications, requires rigorous validation. Here, we develop seventeen disease PGSs by conducting large-scale GWAS meta-analyses, and we validate our scores in out-of-sample prediction analyses. We achieve state-of-the-art predictive performance, consistently matching or outperforming academic an...

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Literature Corpus work: 7cd639d7-347f-5ba2-a6ca-84da782f5176
DOI: 10.1101/2025.08.06.25333145

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