Article

<sup>13</sup> C tracer analysis reveals the landscape of metabolic checkpoints in human CD8 <sup>+</sup> T cell differentiation

2023-05-20

Abstract excerpt

Naïve T cells remain in an actively maintained state of quiescence until activation by antigenic signals, upon which they start proliferation and generation of effector cells to initiate a functional immune response. Metabolic reprogramming is essential to meet the biosynthetic demands of the differentiation process, and failure to do so can promote the development of hypofunctional exhausted T cells. Here we used...

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Literature Corpus work: 848c975c-403a-50b1-b270-3239151a50af
DOI: 10.1101/2023.05.18.541159

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