Article

Differential Impact of Six JAK Inhibitors on Myeloid Cell Differentiation and Their T Cell Stimulatory Capacity: An In Vitro Comparative Study

2025-08-19

Abstract excerpt

<title>Abstract</title> <p>Background Janus kinase inhibitors (JAKis) play a key role in treating autoimmune diseases; however, their immunomodulatory mechanisms, particularly regarding myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs), remain insufficiently understood. This study evaluated the effects of six approved JAKis; tofacitinib (TOF), baricitinib (BAR), peficitinib (PEF), upadacitinib (U...

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Literature Corpus work: 2066f4a7-5eff-56fc-af44-fcf213e79ce9
DOI: 10.21203/rs.3.rs-7246989/v1

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