Article

Metabolic dysregulation induces impaired lymphocyte memory formation during severe SARS-CoV-2 infection

2021-12-08

Abstract excerpt

Cellular metabolic dysregulation is a consequence of COVID-19 infection that is a key determinant of disease severity. To understand the mechanisms underlying these cellular changes, we performed high-dimensional immune cell profiling of PBMCs from COVID-19-infected patients, in combination with single cell transcriptomic analysis of COVID-19 BALFs. Hypoxia, a hallmark of COVID-19 ARDS, was found to elicit a globa...

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Literature Corpus work: 05272d60-c008-50f4-8c1c-3b7b1a9bc2ec
DOI: 10.1101/2021.12.06.471421

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