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Article

Network pharmacology of JAK inhibitors

11 Aug 2016

Abstract excerpt

Small-molecule inhibitors of the Janus kinase family (JAKis) are clinically efficacious in multiple autoimmune diseases, albeit with increased risk of certain infections. Their precise mechanism of action is unclear, with JAKs being signaling hubs for several cytokines. We assessed the in vivo impact of pan- and isoform-specific JAKi in mice by immunologic and genomic profiling. Effects were broad across the...

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PMID: 27516546
DOI: 10.1073/pnas.1610253113

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