Article

Differential impact of six JAK inhibitors on myeloid cell differentiation and T cell stimulatory capacity: An in vitro comparative study

2026-04-16

Abstract excerpt

<title>Abstract</title> <p>Janus kinase inhibitors (JAKis) modulate immune signaling, yet their effects on myeloid lineages and T-cell responses remain incompletely defined. We systematically compared six JAKis—tofacitinib, baricitinib, peficitinib, upadacitinib, filgotinib, and deucravacitinib—in a GM-CSF/IL-4 bone-marrow culture system. Flow cytometry quantified myeloid-derived suppressor cells (MDSCs) and dend...

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Literature Corpus work: 0e90fb8f-1844-5c86-90bd-efdd7fa7b3bd
DOI: 10.21203/rs.3.rs-7882005/v1

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