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Article

Short-term lipopolysaccharide treatment leads to astrocyte activation in LRRK2 G2019S knock-in mice without loss of dopaminergic neurons.

BMC neuroscience - 4 Mar 2025

Ngo Hoang Kieu Chi, Srivastava Akriti, Le Hoang, Ayer Samuel J, Crotty Grace F, Schwarzschild Michael A, Bakshi Rachit

Abstract excerpt

BACKGROUND: The G2019S mutation of LRRK2, which enhances kinase activity of the protein, confers a substantial risk of developing Parkinson's disease (PD). However, the mutation demonstrates incomplete penetrance, suggesting the involvement of other genetic or environmental modulating factors. Here, we investigated whether LRRK2 G2019S knock-in (KI) mice treated with the inflammogen lipopolysaccharide (LPS) could...

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Identifiers

PMID: 40038582
DOI: 10.1186/s12868-025-00939-7
PMCID: PMC11877714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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