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Article

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages.

International journal of molecular sciences - 13 Jan 2023

Oun Asmaa, Hoeksema Emmy, Soliman Ahmed, Brouwer Famke, García-Reyes Fabiola, Pots Henderikus, Trombetta-Lima Marina, Kortholt Arjan, Dolga Amalia M

Abstract excerpt

Dysfunction of the immune system and mitochondrial metabolism has been associated with Parkinson's disease (PD) pathology. Mutations and increased kinase activity of leucine-rich repeat kinase 2 (LRRK2) are linked to both idiopathic and familial PD. However, the function of LRRK2 in the immune cells under inflammatory conditions is contradictory. Our results showed that lipopolysaccharide (LPS) stimulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36675159
DOI: 10.3390/ijms24021644
PMCID: PMC9865464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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