Article
The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Human molecular genetics - 1 Aug 2015
Moehle Mark S, Daher João Paulo Lima, Hull Travis D, Boddu Ravindra, Abdelmotilib Hisham A, Mobley James, Kannarkat George T, Tansey Malú G, West Andrew B
Abstract excerpt
The Leucine rich repeat kinase 2 (LRRK2) gene is genetically and biochemically linked to several diseases that involve innate immunity. LRRK2 protein is highly expressed in phagocytic cells of the innate immune system, most notably in myeloid cells capable of mounting potent pro-inflammatory responses. Knockdown of LRRK2 protein in these cells reduces pro-inflammatory responses. However, the effect of LRRK2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.