The Importance of Regulatory Network Structure for Complex Trait Heritability and Evolution.

doi:10.1093/molbev/msaf174

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Article

The Importance of Regulatory Network Structure for Complex Trait Heritability and Evolution.

Molecular biology and evolution - 30 Jul 2025

Stone Katherine L, Platig John, Quackenbush John, Fagny Maud

Abstract excerpt

Complex traits are determined by many loci-mostly regulatory elements-that, through combinatorial interactions, can affect multiple traits. Such high levels of epistasis and pleiotropy have been proposed in the omnigenic model and may explain why such a large part of complex trait heritability is usually missed by genome-wide association studies, while raising questions about the possibility for such traits to...

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Topics

Gene Regulatory Networks
Quantitative Trait Loci
Polymorphism, Single Nucleotide
Multifactorial Inheritance
Genome-Wide Association Study
Quantitative Trait, Heritable

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Selection, Genetic

Biological Evolution

Evolution, Molecular

Models, Genetic

Phenotype

Epistasis, Genetic

Animals

Source

Open in PubMed Open full text

Identifiers

PMID: 40827705
DOI: 10.1093/molbev/msaf174
PMCID: PMC12362071

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