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Article

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

16 Nov 2018

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial wall-specific mechanisms. One of the annotated genes encodes LMOD1 (Leiomodin 1), a member of the actin filament nucleator family that is highly enriched in smooth muscle-containing tissues such as the artery wall. However, it is still unknown whether LMOD1 is the...

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PMID: 30444878
DOI: 10.1371/journal.pgen.1007755

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