Structural mutations in cancer: mechanistic and functional insights.

Abstract excerpt

Next-generation sequencing (NGS) has enabled the comprehensive and precise identification of many somatic structural mutations in cancer. Analyses integrating point mutation information with data on rearrangements and copy number variation have revealed a higher-order organization of the seemingly random genetic events that lead to cancer. These meta-analyses provide a more refined view of the mutational...

Topics

• Animals
• Genome, Human
• Humans
• Mutation
• Neoplasms
• Oncogenes