Article

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

2018-11-11

Abstract excerpt

The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (P<5×l0 05 ) derived from GWAS and 551 heritable traits from the UK Biobank study (N=334,398). Findings can be investigated using a web application ( http://mrcieu.mrsoftware....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d07feaf-01fb-5ab4-8ea1-3d437e1eb26e
DOI: 10.1101/467910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenomeDOI 10.1101/467910Read

Polygenic risk scores applied to a single cohort reveal pleiotropy among hundreds of human phenotypesSemantic proximity Read

The power of pathway-based polygenic risk scoresSemantic proximity Read

Polygenic risk scores in psychiatry: Will they be useful for clinicians?Semantic proximity Read

PRSet: Pathway-based polygenic risk score analyses and software.Semantic proximity Read

Tutorial: a guide to performing polygenic risk score analyses.Semantic proximity Read

A Systematic Review and Analysis of the Use of Polygenic Scores in Pharmacogenomics.Semantic proximity Read

Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.Semantic proximity Read

Embracing polygenicity: a review of methods and tools for psychiatric genetics research.Semantic proximity Read

Mapping Genetic Architecture of Thousands of Complex Traits Using GWAS Summary StatisticsSemantic proximity Read

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohortsSemantic proximity Read

An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkersSemantic proximity Read

Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers.Semantic proximity Read