Article
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
2020-09-11
Abstract excerpt
<h4>Background</h4> Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies (GWASs). PGS methods differ in which DNA variants are included and the weights assigned to them; some require an independent tuning sample to help inform these choices. PGSs are evaluated in independent target cohor...
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Identifiers and source
- Literature Corpus work
- 10badfa1-f96b-5155-959f-f256141ad909
- DOI
- 10.1101/2020.09.10.20192310