Polygenic risk scores applied to a single cohort reveal pleiotropy among hundreds of human phenotypes

Abstract excerpt

<h4>Background</h4> There is now convincing evidence that pleiotropy across the genome contributes to the correlation between human traits and comorbidity of diseases. The recent availability of genome-wide association study (GWAS) results have made the polygenic risk score (PRS) approach a powerful way to perform genetic prediction and identify genetic overlap among phenotypes. <h4>Methods and findings</h4> Her...

Topics

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• Genetic Pleiotropy
• Genetic Risk Score
• Genome-Wide Association Study
• Multifactorial Inheritance
• Prediction Algorithms
• Risk Factors
• ROC Curve
• UK Biobank

Identifiers and source

Literature Corpus work

4ed0e1b8-cc6b-5aef-b469-e1cf24d20a0d

DOI

10.1101/203257