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Article

Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers.

eLife - 11 Oct 2022

Fang Si, Holmes Michael V, Gaunt Tom R, Davey Smith George, Richardson Tom G

Abstract excerpt

Background: Polygenic scores (PGS) are becoming an increasingly popular approach to predict complex disease risk, although they also hold the potential to develop insight into the molecular profiles of patients with an elevated genetic predisposition to disease. Methods: We sought to construct an atlas of associations between 125 different PGS derived using results from genome-wide association studies and 249...

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Identifiers

PMID: 36219204
DOI: 10.7554/eLife.73951
PMCID: PMC9553209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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