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Article

Tutorial: a guide to performing polygenic risk score analyses.

Nature protocols - 1 Sept 2020

Choi Shing Wan, Mak Timothy Shin-Heng, O'Reilly Paul F

Abstract excerpt

A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's genetic liability to a trait or disease, calculated according to their genotype profile and relevant genome-wide association study (GWAS) data. While present PRSs typically explain only a small fraction of trait variance, their correlation with the single largest contributor to phenotypic variation-genetic liability-has led to...

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Identifiers

PMID: 32709988
DOI: 10.1038/s41596-020-0353-1
PMCID: PMC7612115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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