Article

Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

2022-01-19

Abstract excerpt

COVID-19 shows an unexplained, strong male bias for severity and mortality. Loss of Y (LOY) in myeloid cells is a risk factor candidate in COVID-19 because of associations with many age-related diseases and its effect on transcription of immune genes. We report the highest levels of LOY in cells that are crucial for the development of severe COVID-19 phenotype, such as low-density neutrophils, granulocytes, and mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa675df7-ffcb-5425-b192-71cac3a70734
DOI: 10.1101/2022.01.19.22269521

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Y in leukocytes as a risk factor for critical COVID-19 in menDOI 10.1101/2022.01.19.22269521Read

Loss of Y in leukocytes as a risk factor for critical COVID-19 in menSemantic proximity Read

Loss of chromosome Y shapes the immune cell fate with aging in menSemantic proximity Read

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesisSemantic proximity Read

Genetic Architectures of Myeloid Dysregulation in Severe COVID-19.Semantic proximity Read

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19Semantic proximity Read

Clonal chromosomal mosaicism and loss of chromosome Y in men are risk factors for SARS-CoV-2 vulnerability in the elderlySemantic proximity Read

Immune cells lacking Y chromosome have widespread dysregulation of autosomal genesSemantic proximity Read

Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99.Semantic proximity Read

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19Semantic proximity Read

Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal hematopoiesisSemantic proximity Read

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging menSemantic proximity Read

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.Semantic proximity Read