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Prognostic Significance of Somatic Mutations in Myeloid Cells of Men with Chronic Heart Failure – Interaction Between Loss of Y Chromosome and Clonal Haematopoiesis

24 Jul 2025

Abstract excerpt

AIMS: Age-associated clonal haematopoiesis of indeterminate potential (CHIP) has been linked to increased incidence and worse prognosis of chronic heart failure (CHF). CHIP arises from somatic mutations in haematopoietic stem and progenitor cells. Mosaic loss of Y chromosome (LOY), the most common somatic mutation in male blood cells, increases with age, drives clonal expansion of myeloid cells, and has been...

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PMID: 40702883
DOI: 10.1002/ejhf.3778

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